Abstract | BACKGROUND: METHODS: In this study 50 healthy Filipino infants were enrolled at a village health center in Cabuyao to receive 11-valent diphtheria- and tetanus-conjugated pneumococcal vaccine at 6, 10 and 14 weeks of age (primary series) simultaneously with diphtheria- tetanus-whole cell pertussis/polyribosylribitol phosphate conjugated to tetanus toxoid, hepatitis B virus and oral poliovirus vaccines and at 9 months of age (booster dose) simultaneously with measles vaccine. The alum-adjuvanted study vaccine contained pneumococcal polysaccharide of serotypes 1, 4, 5, 7F, 9V, 19F and 23F conjugated to tetanus protein and pneumococcal polysaccharide of serotypes 3, 6B, 14 and 18C conjugated to diphtheria toxoid. Serum samples for enzyme immunoassay analyses were collected at 6, 10 and 14 weeks and 9 and 10 months of age. RESULTS: Very high geometric mean antibody concentrations (GMCs) against most pneumococcal serotypes were observed after the first three doses of vaccine (range, serotype 23F, 3.89 microg/ml to serotype 4, 23.41 microg/ml) with the exception of serotype 6B and 14, with GMCs of 1.12 and 2.18 microg/ml, respectively. The fourth dose increased the GMCs against most serotypes (range, serotype 14, 1.65 to serotype 19F, 33.43 microg/ml). The maternally derived antibodies did not decrease the response to the vaccine. CONCLUSIONS:
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Authors | Taneli Puumalainen, M Rose Zeta-Capeding, Helena Käyhty, Marilla G Lucero, Kari Auranen, Odile Leroy, Hanna Nohynek |
Journal | The Pediatric infectious disease journal
(Pediatr Infect Dis J)
Vol. 21
Issue 4
Pg. 309-14
(Apr 2002)
ISSN: 0891-3668 [Print] United States |
PMID | 12075762
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Diphtheria-Tetanus Vaccine
- Pneumococcal Vaccines
- Vaccines, Conjugate
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Topics |
- Antibody Formation
- Diphtheria-Tetanus Vaccine
(administration & dosage, immunology)
- Dose-Response Relationship, Drug
- Female
- Humans
- Infant
- Kinetics
- Male
- Philippines
- Pneumococcal Vaccines
(administration & dosage, immunology)
- Vaccines, Conjugate
(administration & dosage, immunology)
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