Abstract | BACKGROUND: OBJECTIVES: METHODS: RESULTS: A mean reduction of 2.4 +/- 6.2 per 0.36 cm2 in hairs of diameter > 40 microm was observed in the cyproterone acetate group (P = 0.05) and a mean increase of 6.5 +/- 9 per 0.36 cm2 in the minoxidil group (P < 0.001). Comparison of the total number of hairs at 12 months and the body mass index (BMI) revealed a borderline positive correlation in the cyproterone acetate group (r = 0.39, P = 0.06) and a negative correlation in the minoxidil group (r = -0.42, P < 0.05). No significant difference was observed in the total number of hairs among cyproterone acetate patients according to the presence or absence of other symptoms of hyperandrogenism, whereas in the minoxidil group, the total number of new hairs was higher in patients with isolated alopecia (Delta = 8.1; P < 0.05). Variations in scalp seborrhoea were significant in both groups, but the result was better (for acne and hirsutism as well) in the cyproterone acetate group than in the minoxidil group (P < 0.001). CONCLUSIONS:
Minoxidil treatment was more effective in the absence of other signs of hyperandrogenism, hyperseborrhoea, and menstrual cycle modifications when the BMI was low, and when nothing argued in favour of biochemical hyperandrogenism. Cyproterone acetate treatment was more effective when other signs were present and when the BMI was elevated, factors that favoured a diagnosis of biochemical hyperandrogenism.
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Authors | P Vexiau, C Chaspoux, P Boudou, J Fiet, C Jouanique, N Hardy, P Reygagne |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 146
Issue 6
Pg. 992-9
(Jun 2002)
ISSN: 0007-0963 [Print] England |
PMID | 12072067
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Androgen Antagonists
- Contraceptives, Oral, Combined
- Ethinyl Estradiol
- Cyproterone Acetate
- Minoxidil
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Topics |
- Administration, Topical
- Adult
- Alopecia
(drug therapy)
- Androgen Antagonists
(administration & dosage)
- Body Mass Index
- Contraceptives, Oral, Combined
(administration & dosage)
- Cyproterone Acetate
(administration & dosage)
- Dermatitis, Seborrheic
(complications)
- Ethinyl Estradiol
(administration & dosage)
- Female
- Humans
- Hyperandrogenism
(complications)
- Minoxidil
(administration & dosage)
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