Abstract | AIM: PATIENTS AND METHODS: This retrospective study concerned 54 patients with insulinoma (n=29) or gastrinoma (n=26) operated on between March 1991 and March 2000 and who had at least one among the two tested examinations. Forty-two patients had scintigraphy (17 with insulinoma, 25 with gastrinoma), 47 had endoscopic ultrasonography (28 with insulinoma, 17 with gastrinoma). One of the ten patients with MEN 1 had both tumors. All diagnosis were confirmed by histologic examination. RESULTS: The sensitivity of scintigraphy for the localization of insulinomas was 47%. There was one false positive. Sensitivity of endoscopic ultrasonography for insulinomas was 85%. The sensitivity of scintigraphy in the detection of gastrinomas was 65% for the tumors in the duodenopancreatic area, 20% for the tumors in the pancreatic tail and 71% for metastasis. The sensitivity of endoscopic ultrasonography was 46% for duodenal tumors, 75% for pancreatic tumors and 57% for lymph node metastasis. The combination of both localization studies increased sensitivity to 94%. CONCLUSION: Endoscopic ultrasonography and somatostatin receptor scintigraphy are the gold standard for localization of gastrinomas. Association of both examinations increases the sensitivity. Scintigraphy for the detection of insulinomas should be performed when endoscopic ultrasonography is negative.
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Authors | Eric Mirallié, François Pattou, Philippe Malvaux, Bernard Filoche, Jean-Michel Godchaux, Vincent Maunoury, Laurent Palazzo, Jean Lefebvre, Damien Huglo, Jean-Claude Paris, Bruno Carnaille, Charles Proye |
Journal | Gastroenterologie clinique et biologique
(Gastroenterol Clin Biol)
Vol. 26
Issue 4
Pg. 360-6
(Apr 2002)
ISSN: 0399-8320 [Print] France |
Vernacular Title | Valeurs de l'échoendoscopie et de la scintigraphie des récepteurs de la somatostatine dans la localisation pré-opératoire des insulinomes et gastrinomes. |
PMID | 12070411
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Child
- Duodenal Neoplasms
(diagnostic imaging)
- Endosonography
- Female
- Gastrinoma
(diagnostic imaging)
- Humans
- Insulinoma
(diagnostic imaging)
- Male
- Middle Aged
- Pancreatic Neoplasms
(diagnostic imaging)
- Receptors, Somatostatin
(analysis)
- Retrospective Studies
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