Nedocromil sodium ophthalmic solution 2% twice daily in patients with allergic conjunctivitis.

Abstract

In a multicenter, open-label evaluation, 1098 patients with ocular itching and a history of perennial or seasonal allergic conjunctivitis instilled one drop of nedocromil sodium 2% twice daily in each eye. Ocular symptoms, signs, and global improvement were assessed at baseline and 1 month; satisfaction scores, quality-of-life variables, and adverse events were also recorded. Significant improvements from baseline (P<.012) occurred in mean severity scores for itching, burning, stinging, watering, swelling, tired eyes, dryness, gritty sensation, eye pain, foreign-body sensation, and light sensitivity. Physicians reported significant reductions (P<.0001) in bulbar conjunctival redness and swelling. Two thirds of patients (634/954) and three fourths of physicians (710/954) reported at least 75% improvement in overall condition after 1 month. The most common adverse events were burning (2.7%) and unpleasant taste (1.4%); headache (1.2%) and adverse events leading to discontinuation (1.3%) were rare. Patients reported significant improvement (P<.001) in their ability to perform daily activities; 65% were more satisfied with nedocromil than with their typical medication. Physicians would prescribe nedocromil again to 80% of the patients. Nedocromil sodium 2% twice daily was effective and safe for the treatment of symptoms of allergic conjunctivitis, significantly improving quality of life and producing high rates of user and physician satisfaction.

• Authors: Joseph Tauber, Alocril Community Allergy Trial Study Group
• Journal: Advances in therapy (Adv Ther) 2002 Mar-Apr Vol. 19 Issue 2 Pg. 73-84 ISSN: 0741-238X [Print] United States
• PMID: 12069370 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Allergic Agents
• Anti-Inflammatory Agents
• Ophthalmic Solutions
• Nedocromil

Topics

• Activities of Daily Living
• Adolescent
• Adult
• Aged
• Anti-Allergic Agents (administration & dosage, adverse effects)
• Anti-Inflammatory Agents (administration & dosage, adverse effects)
• Child
• Conjunctivitis, Allergic (drug therapy)
• Drug Administration Schedule
• Female
• Humans
• Male
• Middle Aged
• Nedocromil (administration & dosage, adverse effects)
• Ophthalmic Solutions (administration & dosage)
• Quality of Life
• Time Factors
• Treatment Outcome
• United States