HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Effects of two dimeric iodinated contrast media on renal medullary blood perfusion and oxygenation in dogs.

AbstractRATIONALE AND OBJECTIVES:
To compare the effects of two iodinated contrast media, iodixanol and ioxaglate, on outer medullary blood flow (MBF) and oxygen tension (MPO(2)) in the dog kidney.
METHODS:
Iodixanol and ioxaglate were injected selectively into the renal artery (320 mgI/kg) of anesthetized Beagle dogs. MBF and MPO(2) were measured with a laser-Doppler probe and an oxygen-sensing microelectrode implanted in the outer medulla. Urine samples were collected for viscosity and osmolality measurements.
RESULTS:
Both contrast media produced a moderate decrease in MBF and MPO(2). The hypoperfusion and hypoxia lasted significantly longer with iodixanol than with ioxaglate. Theophylline, an adenosine receptor antagonist, partially prevented iodixanol-induced hypoxia. Urine viscosity was dramatically increased by iodixanol but not by ioxaglate. Urine osmolality did not differ significantly between groups.
CONCLUSION:
Iodixanol produced a more sustained medullary hypoxia than ioxaglate when injected selectively into the dog renal artery. This may lead to hypoxic cellular damage and subsequent impairment of kidney functions.
AuthorsEric Lancelot, Jean-Marc Idée, Christine Laclédère, Robin Santus, Claire Corot
JournalInvestigative radiology (Invest Radiol) Vol. 37 Issue 7 Pg. 368-75 (Jul 2002) ISSN: 0020-9996 [Print] United States
PMID12068157 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Contrast Media
  • Triiodobenzoic Acids
  • iodixanol
  • Theophylline
  • Ioxaglic Acid
Topics
  • Animals
  • Contrast Media (pharmacology)
  • Dogs
  • Injections, Intra-Arterial
  • Ioxaglic Acid (pharmacology)
  • Kidney Medulla (blood supply, drug effects, metabolism)
  • Male
  • Oxygen Consumption (drug effects)
  • Renal Artery
  • Renal Circulation (drug effects)
  • Theophylline (pharmacology)
  • Triiodobenzoic Acids (pharmacology)
  • Viscosity

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: