Abstract |
Zinostatin stimalamer ( SMANCS) is a lipophilic intra-arterial chemotherapeutic agent for hepatocellular carcinoma (HCC). In our previous study, transcatheter arterial infusion chemotherapy using SMANCS for HCC showed a response rate of 20%. In an effort to obtain a superior anti- tumor effect against HCC, we conducted a phase II study of transcatheter arterial embolization (TAE) using SMANCS and gelatin sponge in 50 chemotherapy-naive patients with HCC. Four milligrams SMANCS plus 4 ml lipiodol emulsion was injected into the hepatic artery, followed by an injection of gelatin sponge. The responses were evaluated by computed tomography (CT) 1 month after treatment and thereafter every 3-4 months. One patient (2%) showed complete response and 15 patients (30%) had partial response resulting in an overall response rate of 32% (16/50; 95% confidence interval 19-45%). In 33 patients (66%), the disease remained stable, and 1 patient (2%) showed progressive disease. In 35 patients (70%), the rate of necrotic area to whole tumor was more than 50% according to the evaluation method using lipiodol accumulation in CT. The 1-, 3- and 5-year survival rates were 90, 55 and 19%, respectively. Grade 3 hematological toxicity was observed as thrombocytopenia in 2 patients (4%). Grade 3 and 4 non-hematological toxicity ( liver dysfunction) occurred in 17 (34%) and 7 patients (14%), respectively. TAE using SMANCS, which was well tolerated, may be an effective treatment for advanced HCC.
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Authors | Takuji Okusaka, Shuichi Okada, Hideki Ueno, Masafumi Ikeda, Ryoko Iwata, Hiroyoshi Furukawa, Kenichi Takayasu, Noriyuki Moriyama, Tosiya Sato, Keiko Sato |
Journal | Oncology
(Oncology)
Vol. 62
Issue 3
Pg. 228-33
( 2002)
ISSN: 0030-2414 [Print] Switzerland |
PMID | 12065870
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2002 S. Karger AG, Basel |
Chemical References |
- Antineoplastic Agents
- Maleic Anhydrides
- Polystyrenes
- poly(maleic acid-styrene)neocarzinostatin
- Zinostatin
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Topics |
- Adult
- Aged
- Antineoplastic Agents
(administration & dosage, adverse effects)
- Carcinoma, Hepatocellular
(mortality, pathology, therapy)
- Chemoembolization, Therapeutic
- Female
- Humans
- Liver Neoplasms
(mortality, pathology, therapy)
- Male
- Maleic Anhydrides
(administration & dosage, adverse effects)
- Middle Aged
- Polystyrenes
(administration & dosage, adverse effects)
- Survival Rate
- Treatment Outcome
- Zinostatin
(administration & dosage, adverse effects, analogs & derivatives)
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