Abstract |
Neurosyphilis has been reported in HIV-infected patients previously treated with penicillin G benzathine, which does not achieve treponemicidal levels in cerebrospinal fluid. Therapy combining benzylpenicillin G and its repository form benzylpenicillin G benethamine could be a potentially effective alternative enhanced regimen for treating latent syphilis in HIV-infected patients because peak serum and cerebrospinal fluid concentrations would be achieved early post-administration by the former molecule and sustained for 24 h due to the prolonged half-life of the latter. In this study, 23 asymptomatic HIV and Treponema pallidum co-infected patients received 10 d of combined therapy (2 M IU intramuscular once daily) and were followed up at 3, 6 and 12 months. None experienced side effects or clinical symptoms. Of the 18 patients who were evaluated 1 y later, 8 (44.4%) exhibited serological treatment failure, defined as a positive serum rapid plasma reagin test. In conclusion, a 10-d regimen combining penicillin G and penicillin G benethamine seems to be of no benefit compared to currently recommended treatment.
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Authors | Pierre Tattevin, Patrick Renault, Véronique Joly, Rui Bastos, Elisabeth Coelho, Christian Adda, Anne Ebel, Patrick Yeni |
Journal | Scandinavian journal of infectious diseases
(Scand J Infect Dis)
Vol. 34
Issue 4
Pg. 257-61
( 2002)
ISSN: 0036-5548 [Print] England |
PMID | 12064687
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Penicillins
- Penicillin G Benzathine
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Topics |
- Adult
- Drug Therapy, Combination
- Female
- HIV
(pathogenicity)
- HIV Infections
(complications, pathology)
- Humans
- Male
- Middle Aged
- Mozambique
- Penicillin G Benzathine
(chemistry, metabolism, therapeutic use)
- Penicillins
(therapeutic use)
- Syphilis, Latent
(complications, drug therapy)
- Time Factors
- Treatment Outcome
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