Abstract |
A good CD8+ response is required for immunity to many intracellular pathogens. Traditional antigen delivery using isolated sub-units or killed pathogens and adjuvant stimulates strong antibody responses but weak T-cell reactivity. Attenuated vaccines are usually more effective. The prime-boost delivery system based on immunisation with a naked DNA antigen-gene construct followed by boosting with an attenuated vaccinia virus expressing the same antigen is proving to be a powerful way to stimulate antigen-specific CD8 responses. Success using single epitopes is possible in malaria and we believe this approach holds much promise for other apicomplexan parasites such as Theileria spp.
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Authors | R Hall, R Adamson, N Boulter |
Journal | Parasitology research
(Parasitol Res)
Vol. 88
Issue 13 Suppl 1
Pg. S45-7
(May 2002)
ISSN: 0932-0113 [Print] Germany |
PMID | 12051610
(Publication Type: Journal Article, Review)
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Chemical References |
- Protozoan Vaccines
- Vaccines, Synthetic
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Topics |
- Animals
- Apicomplexa
(genetics, immunology)
- Immunization, Secondary
(methods)
- Protozoan Infections
(prevention & control)
- Protozoan Vaccines
(administration & dosage)
- Theileria
(genetics, immunology)
- Theileriasis
(prevention & control)
- Vaccines, Synthetic
(administration & dosage)
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