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Prime-boost: the way forward for recombinant vaccines against apicomplexan parasites. A Theileria perspective.

Abstract
A good CD8+ response is required for immunity to many intracellular pathogens. Traditional antigen delivery using isolated sub-units or killed pathogens and adjuvant stimulates strong antibody responses but weak T-cell reactivity. Attenuated vaccines are usually more effective. The prime-boost delivery system based on immunisation with a naked DNA antigen-gene construct followed by boosting with an attenuated vaccinia virus expressing the same antigen is proving to be a powerful way to stimulate antigen-specific CD8 responses. Success using single epitopes is possible in malaria and we believe this approach holds much promise for other apicomplexan parasites such as Theileria spp.
AuthorsR Hall, R Adamson, N Boulter
JournalParasitology research (Parasitol Res) Vol. 88 Issue 13 Suppl 1 Pg. S45-7 (May 2002) ISSN: 0932-0113 [Print] Germany
PMID12051610 (Publication Type: Journal Article, Review)
Chemical References
  • Protozoan Vaccines
  • Vaccines, Synthetic
Topics
  • Animals
  • Apicomplexa (genetics, immunology)
  • Immunization, Secondary (methods)
  • Protozoan Infections (prevention & control)
  • Protozoan Vaccines (administration & dosage)
  • Theileria (genetics, immunology)
  • Theileriasis (prevention & control)
  • Vaccines, Synthetic (administration & dosage)

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