Tc-99m sulfur colloid and Tc-99m tagged red blood cell methods are comparable for detecting lower gastrointestinal bleeding in clinical practice.

Abstract

PURPOSE:

The objective of this study was to determine whether the Tc-99m red blood cells (Tc-99m RBC) method has a true advantage over the Tc-99m sulfur colloid (Tc-99m SC) technique in a busy clinical practice for detecting and localizing lower gastrointestinal bleeding sites.

METHODS:

Three hundred fifty-nine consecutive gastrointestinal bleeding studies performed during the past 4 years were reviewed retrospectively. One hundred ninety-three scans were obtained with Tc-99m SC (scan duration, 30 minutes) and 138 studies were performed after the administration of Tc-99m RBC (scan duration, 1 hour). In addition, 28 examinations with Tc-99m SC were followed immediately by Tc-99m RBC scans for a duration of several hours. The results of the two methods were analyzed and the performance of the two techniques was compared.

RESULTS:

Among 193 scans performed using the Tc-99m SC method, 47 (24.4%) successfully identified the location of the bleeding site, whereas in 138 scans performed using Tc-99m RBC, 38 (27.5%) were successful for this purpose. In the remaining 28 scans in which the Tc-99m SC scan was followed by the Tc-99m RBC study, only 4 (14.3%) positive bleeding sites were identified after a prolonged imaging period.

DISCUSSION:

The theoretical advantages of the Tc-99m RBC technique compared with the Tc-99m SC method cannot be substantiated by this study. Our findings suggest that the efficacy of these two methods is nearly equal at a practical level.

CONCLUSION:

The simpler and cost-effective Tc-99m SC method is as efficient as the Tc-99m RBC method when the scanning time is limited to 1 hour and optimal imaging and interpretation schemes are used.

• Authors: Fabio Ponzo, Hongming Zhuang, Frank M Liu, Lester B Lacorte, Bahar Moussavian, Sunny Wang, Abass Alavi
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 27 Issue 6 Pg. 405-9 (Jun 2002) ISSN: 0363-9762 [Print] United States
• PMID: 12045430 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Radiopharmaceuticals
• Technetium Tc 99m Sulfur Colloid
• Sodium Pertechnetate Tc 99m

Topics

• Adult
• Aged
• Aged, 80 and over
• Erythrocytes (diagnostic imaging)
• Gastrointestinal Hemorrhage (blood, diagnostic imaging)
• Humans
• Radionuclide Imaging
• Radiopharmaceuticals (pharmacokinetics)
• Retrospective Studies
• Sensitivity and Specificity
• Sodium Pertechnetate Tc 99m
• Technetium Tc 99m Sulfur Colloid (pharmacology)
• Time Factors