Omapatrilat provides long-term control of hypertension: a randomized trial of treatment withdrawal.

Omapatrilat simultaneously inhibits neutral endopeptidase and angiotensin-converting enzyme, increasing levels of vasodilatory peptides while decreasing production of angiotensin II. This study evaluated the clinical effects of withdrawal of omapatrilat after a patient's hypertension had been controlled (seated diastolic blood pressure <90 mm Hg) on omapatrilat for at least 6 months, with or without adjunctive antihypertensive medications. This double-blind study randomized 83 patients to receive either their established omapatrilat dose or placebo for 8 weeks; any concomitant antihypertensive medications were kept constant. Patients continuing on omapatrilat had no change in blood pressure. Patients whose chronic omapatrilat treatment was replaced by placebo had clinically important increases in both systolic (+16.5 mm Hg) and diastolic ((+9.6 mm Hg) blood pressures (both p<0.001). An increase in blood pressure was also seen in patients who were taking adjunctive antihypertensive medications prior to withdrawal of omapatrilat. This study demonstrates that when compared to withdrawal placebo, omapatrilat maintains clinically and statistically significant blood pressure reductions.
AuthorsR Guthrie, R A Reeves
JournalJournal of clinical hypertension (Greenwich, Conn.) (J Clin Hypertens (Greenwich)) 2002 May-Jun Vol. 4 Issue 3 Pg. 169-72 ISSN: 1524-6175 [Print] United States
PMID12045365 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
CopyrightCopyright 2002 Le Jacq
Chemical References
  • Angiotensin-Converting Enzyme Inhibitors
  • Pyridines
  • Thiazepines
  • omapatrilat
  • Adult
  • Aged
  • Angiotensin-Converting Enzyme Inhibitors (administration & dosage)
  • Blood Pressure Determination
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Follow-Up Studies
  • Humans
  • Hypertension (diagnosis, drug therapy)
  • Male
  • Middle Aged
  • Pyridines (administration & dosage)
  • Reference Values
  • Severity of Illness Index
  • Thiazepines (administration & dosage)
  • Time Factors
  • Treatment Outcome
  • Withholding Treatment

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