Abstract |
Omega-3 polyunsaturated fatty acids have been effective in reducing cardiovascular mortality in the recent GISSI-Prevenzione study. In a post-hoc analysis of this study an important observation has been the reduction of sudden cardiac death. The hypothesis that a protection from sudden death occurs because of antiarrhythmic effects of omega-3 fatty acids is supported by studies on cellular and animal models. A few intervention studies before the GISSI-Prevenzione and several retrospective analyses of epidemiological studies, in which nutritional variables connected with the intake of omega-3 fatty acids had been recorded, also support such a hypothesis. This review critically summarizes this type of evidence and indicates current research directions for its further validation.
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Authors | Raffaele De Caterina, Rosalinda Madonna |
Journal | Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology
(Ital Heart J Suppl)
Vol. 3
Issue 3
Pg. 297-308
(Mar 2002)
ISSN: 1129-4728 [Print] Italy |
Vernacular Title | Effetti antiaritmici degli acidi grassi omega-3. Una rassegna. |
PMID | 12040845
(Publication Type: English Abstract, Journal Article, Review)
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Chemical References |
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Topics |
- Arrhythmias, Cardiac
(prevention & control)
- Clinical Trials as Topic
- Death, Sudden, Cardiac
(prevention & control)
- Fatty Acids, Omega-3
(metabolism, pharmacology)
- Forecasting
- Humans
- Membrane Potentials
(drug effects, physiology)
- Prospective Studies
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