A randomized trial of danazol pretreatment prior to endometrial resection.

Abstract

OBJECTIVES:

To assess the effect of danazol pretreatment in women undergoing endometrial resection for dysfunctional uterine bleeding.

STUDY DESIGN:

A total of 132 patients were randomly divided into danazol pretreated and untreated groups. Endometrial resection was carried out using a 24Fr cutting wire loop electrode and 1.5% glycine as the distension media. Patients were followed-up for 6 years. The t-test and Chi-square tests were used to test differences between the two groups.

RESULTS:

The mean endometrial thickness, fluid used, fluid deficit, weight of resected tissue and duration of surgery were significantly greater in the unprepared group. Over 70% of patients in both the groups achieved amenorrhoea or spotting. Two (1.5%) patients underwent a repeat procedure and two (1.5%) others a hysterectomy, while the rest had hypomenorrhoea. The perimenstrual symptoms also showed significant improvement. No statistically significant difference was found in the outcomes of the two groups.

CONCLUSION:

Endometrial resection is an effective alternative to hysterectomy and pretreatment of the endometrium is not necessary for good outcomes.

• Authors: Alka Kriplani, Ranjit Manchanda, Jyoti Nath, Deep Takkar
• Journal: European journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol) Vol. 103 Issue 1 Pg. 68-71 (Jun 10 2002) ISSN: 0301-2115 [Print] Ireland
• PMID: 12039468 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Estrogen Antagonists
• Danazol

Topics

• Adult
• Biopsy
• Danazol (therapeutic use)
• Endometrial Hyperplasia (pathology, surgery)
• Endometrial Neoplasms (diagnosis, surgery)
• Endometrium (pathology, surgery)
• Estrogen Antagonists (therapeutic use)
• Female
• Humans
• Hysterectomy
• Hysteroscopy
• Leiomyosarcoma (diagnosis, surgery)
• Menorrhagia (surgery)
• Pelvic Pain
• Polyps (pathology, surgery)
• Premedication
• Treatment Outcome
• Uterine Hemorrhage (surgery)
• Uterine Neoplasms (diagnosis, pathology)