Abstract | OBJECTIVES: STUDY DESIGN: This was a single-center, nonrandomized, open-label, single-dose trial of HCIN- DDAVP. Nine boys with hemophilia A, 8 girls with mild VWD, and 8 boys with mild VWD were evaluated. HCIN- DDAVP responses were compared with historic IV- DDAVP responses in 13 of the patients. RESULTS: CONCLUSION: We conclude that administration of 150 microg of high concentration intranasal desmopressin is safe and effective in patients weighing < or = 50 kg with mild hemophilia A or mild type 1 VWD.
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Authors | Joan Cox Gill, Marilyn Ottum, Bruce Schwartz |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 140
Issue 5
Pg. 595-9
(May 2002)
ISSN: 0022-3476 [Print] United States |
PMID | 12032528
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hemostatics
- Deamino Arginine Vasopressin
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Topics |
- Administration, Intranasal
- Adolescent
- Analysis of Variance
- Child
- Child, Preschool
- Deamino Arginine Vasopressin
(administration & dosage, adverse effects, pharmacokinetics)
- Female
- Hemophilia A
(drug therapy)
- Hemostatics
(administration & dosage, adverse effects, pharmacokinetics)
- Humans
- Infant
- Infusions, Intravenous
- Male
- von Willebrand Diseases
(drug therapy)
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