Abstract | OBJECTIVE: BACKGROUND: DESIGN: Three randomized, placebo-controlled, double-blind, parallel-group trials, in a total of 2676 patients, were performed to confirm the clinical efficacy of frovatriptan 2.5 mg for the acute treatment of migraine. RESULTS: In all three studies, headache response 2 hours after frovatriptan dosing was significantly greater than that seen with placebo (P < or = .001) with approximately a two-fold measure of effect over placebo for headache response at 2 and 4 hours postdosing. Time to headache response occurred within 1.5 hours in a substantial proportion of patients. The incidence of 24-hour headache recurrence with frovatriptan was low (10% to 25%). Frovatriptan therapy also was associated with a high degree of patient satisfaction. CONCLUSIONS:
Frovatriptan represents a consistently effective acute treatment for migraine and accompanying symptoms.
|
Authors | R Ryan, G Géraud, J Goldstein, R Cady, C Keywood |
Journal | Headache
(Headache)
Vol. 42 Suppl 2
Pg. S84-92
(Apr 2002)
ISSN: 0017-8748 [Print] United States |
PMID | 12028324
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
|
Chemical References |
- Carbazoles
- Serotonin Receptor Agonists
- Tryptamines
- frovatriptan
|
Topics |
- Adult
- Aged
- Carbazoles
(therapeutic use)
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Migraine Disorders
(drug therapy)
- Serotonin Receptor Agonists
(therapeutic use)
- Time Factors
- Treatment Outcome
- Tryptamines
|