In vitro antibacterial activity of S-4661, a new parenteral carbapenem, against urological pathogens isolated from patients with complicated urinary tract infections.

Abstract

The antibacterial activity of S-4661, a new parenteral carbapenem antibiotic, was assessed against the major urological pathogens isolated from patients with complicated urinary tract infections. S-4661 was slightly less active than imipenem and panipenem, but more active than meropenem and ceftazidime against Gram-positive bacteria. Against Gram-negative bacteria, S-4661 was similar to meropenem, similar to or more effective than imipenem, and more active than panipenem and ceftazidime. Thus S-4661 possesses potent and well-balanced wide-spectrum antibacterial activity against various urological pathogens.

• Authors: S Nomura, A Nagayama
• Journal: Journal of chemotherapy (Florence, Italy) (J Chemother) Vol. 14 Issue 2 Pg. 155-60 (Apr 2002) ISSN: 1120-009X [Print] England
• PMID: 12017370 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Carbapenems
• Thienamycins
• Imipenem
• Ceftazidime
• Doripenem
• Meropenem

Topics

• Anti-Bacterial Agents (pharmacology)
• Bacteria (drug effects, isolation & purification)
• Carbapenems (pharmacology)
• Ceftazidime (pharmacology)
• Doripenem
• Humans
• Imipenem (pharmacology)
• In Vitro Techniques
• Meropenem
• Microbial Sensitivity Tests
• Thienamycins (pharmacology)
• Urinary Tract Infections (microbiology)