Remission of West syndrome associated with valproate hepatotoxicity.

Abstract

A 6-month-old girl developed West syndrome and it remitted in association with valproate-induced hepatic dysfunction. Plasma -alanine elevated after valproate hepatotoxicity, which seemed to be a possible cause of remission. The patient has been seizure-free with normal electroencephalogram for 12 months without any anticonvulsants. Her developmental milestones were within normal limits at the age of 18 months.

• Authors: Tohshin Go
• Journal: Brain & development (Brain Dev) Vol. 24 Issue 4 Pg. 257-9 (Jun 2002) ISSN: 0387-7604 [Print] Netherlands
• PMID: 12015170 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticonvulsants
• beta-Alanine
• Valproic Acid

Topics

• Anticonvulsants (adverse effects)
• Chemical and Drug Induced Liver Injury
• Electroencephalography
• Female
• Humans
• Infant
• Liver Diseases (blood)
• Spasms, Infantile (blood, diagnosis, drug therapy)
• Valproic Acid (adverse effects)
• beta-Alanine (blood)