Inhaled nedocromil sodium for persistent cough in children.

Abstract

The efficacy of inhaled nedocromil sodium (NS) for children with a persistent cough was studied. Children aged 4-12 years with a persistent cough for >1 month were recruited and entered a 2-week baseline period during which an asthma diary was kept. Children with a cough score of >20 received inhaled NS via a spacer, 4mg qid for 2 weeks followed by 4mg bd for another 4 weeks. Twenty-two (42%) of 52 children recruited fulfilled treatment criteria. Four children were withdrawn from the study (2 developed wheezing and 2 were not compliant). The baseline cough score (29.1 +/- 13.6) improved after 2 weeks of treatment (15.2 +/- 9.3, p < 0.01) and improvement was sustained after 6 weeks (14.2 +/- 13.0, p = 0.01). Parents and patients had a more favourable perception of its efficacy compared to physicians (72% vs 50%, p = 0.01) Inhaled NS may be considered for treatment of persistent cough in children.

• Authors: P W Chan, J A Debruyne
• Journal: The Medical journal of Malaysia (Med J Malaysia) Vol. 56 Issue 4 Pg. 408-13 (Dec 2001) ISSN: 0300-5283 [Print] Malaysia
• PMID: 12014758 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Nedocromil

Topics

• Administration, Inhalation
• Anti-Inflammatory Agents (administration & dosage, therapeutic use)
• Child
• Child, Preschool
• Cough (drug therapy)
• Female
• Humans
• Male
• Nedocromil (administration & dosage, therapeutic use)