Medical management of early fetal demise using sublingual misoprostol.

Abstract

The aim of this study was to determine the efficacy of mifepristone in combination with sublingual misoprostol for the medical management of early fetal demise. Fifty-six consecutive women were studied prospectively. The mean (SD) gestation at diagnosis was 9.6 weeks (1.84). Four women had complete miscarriage with mifepristone alone. The overall success rate was 83.9% and the median induction-miscarriage interval was 8.19 hours (range 0.83 to 37.50 hours). Of those women who had a successful outcome, 91.5% were satisfied with the regimen. Sublingual misoprostol in combination with mifepristone is an effective and safe alternative to vaginal or oral misoprostol in the management of early fetal demise.

• Authors: Prabhath T Wagaarachchi, Premila W Ashok, Norman C Smith, Allan Templeton
• Journal: BJOG : an international journal of obstetrics and gynaecology (BJOG) Vol. 109 Issue 4 Pg. 462-5 (Apr 2002) ISSN: 1470-0328 [Print] England
• PMID: 12013170 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Abortifacient Agents, Nonsteroidal
• Abortifacient Agents, Steroidal
• Misoprostol
• Mifepristone

Topics

• Abortifacient Agents, Nonsteroidal (administration & dosage)
• Abortifacient Agents, Steroidal (administration & dosage)
• Abortion, Induced (methods)
• Administration, Intravaginal
• Administration, Sublingual
• Adolescent
• Adult
• Drug Therapy, Combination
• Female
• Fetal Death
• Humans
• Mifepristone (administration & dosage)
• Misoprostol (administration & dosage)
• Pilot Projects
• Pregnancy
• Prospective Studies
• Scotland