Abstract | PURPOSE: To evaluate the volume of micro- and macroadenomas in quinagolide-treated patients with resistance to or intolerance of bromocriptine. MATERIAL AND METHODS: RESULTS: The average volume reduction of macroadenomas was 324 mm3 (46%) and that of microadenomas 73 mm3 (57%). The level of prolactin secreted by macroadenomas was reduced by an average of 163 microg/l (65%) and that by microadenomas of 113 microg (73%). In 2 microadenomas and in 1 macroadenoma, signal intensity changed during the treatment in T1-weighted images. In follow-up no changes in signal intensity were seen in 8 adenomas in non-contrast T1-weighted images. A haemorrhagic lesion was seen in 1 macroadenoma before treatment, but it disappeared during treatment. CONCLUSION:
Quinagolide was found to be an effective alternative to bromocriptine in cases with drug intolerance or resistance, and MR imaging a suitable method for the follow-up of macro- and microadenomas.
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Authors | E Ilkko, T Tikkakoski, P Salmela, J Pyhtinen, M Kurunlahti |
Journal | Acta radiologica (Stockholm, Sweden : 1987)
(Acta Radiol)
Vol. 43
Issue 2
Pg. 125-9
(Mar 2002)
ISSN: 0284-1851 [Print] England |
PMID | 12010287
(Publication Type: Journal Article)
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Chemical References |
- Aminoquinolines
- Dopamine Agonists
- quinagolide
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Topics |
- Adenoma
(drug therapy)
- Adult
- Aminoquinolines
(therapeutic use)
- Dopamine Agonists
(therapeutic use)
- Female
- Humans
- Magnetic Resonance Imaging
- Pituitary Neoplasms
(drug therapy)
- Retrospective Studies
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