Abstract | BACKGROUND: Convergent evidence from in vivo and in vitro studies of schizophrenia have implicated the mesial temporal lobe as a primary site of pathological change in this disorder. We have previously reported decreased neurotensin receptor density in layer II of the intermediate entorhinal cortex (ERC) in schizophrenia, a finding seen elsewhere but not seen in more caudal ERC. METHODS: To study neuroanatomic and diagnostic specificity, we measured the density of neurotensin receptors in the intermediate and caudal ERC and hippocampal formation of schizophrenic, affective disorder control subjects, and normal control subjects. Slide-based radioligand binding was used to perform these studies. RESULTS: CONCLUSIONS: These findings demonstrate region-specific changes in neurotensin receptor binding levels in the mesial temporal lobe; however, there is no clear diagnostic specificity for these changes, because they were seen to varying degrees in both schizophrenia and affective disorders.
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Authors | Emad H Hamid, Thomas M Hyde, Michael F Egan, Steve S Wolf, Mary M Herman, Charles B Nemeroff, Joel E Kleinman |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 51
Issue 10
Pg. 795-800
(May 15 2002)
ISSN: 0006-3223 [Print] United States |
PMID | 12007453
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Binding, Competitive
- Cell Count
- Cell Culture Techniques
- Entorhinal Cortex
(metabolism, pathology)
- Female
- Hippocampus
(metabolism)
- Humans
- Image Processing, Computer-Assisted
- Male
- Middle Aged
- Mood Disorders
(metabolism)
- Receptors, Neurotensin
(metabolism)
- Schizophrenia
(metabolism)
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