Abstract | OBJECTIVE: DATA SOURCES AND STUDY SELECTION: DATA EXTRACTION AND SYNTHESIS: During hematopoietic stem cell transplantation, pulmonary dysfunction (manifesting as hypoxia), central nervous system dysfunction (detected by alteration of the Mini-Mental Status Exam), and hepatic dysfunction (presenting as the syndrome of hepatic veno-occlusive disease) are all associated with significant decreases in the levels of antithrombin III and protein C and an increase in the platelet transfusion requirement. Each of these three organ dysfunctions is associated with a high likelihood of being followed by the other two and, eventually, death. Patients with these organ dysfunctions have higher levels of interleukin-6, interleukin-10, and tumor necrosis factor-alpha than patients who never develop these complications. Mortality rates for patients with these organ dysfunctions vary from 15% in patients with only one organ dysfunction to 100% in patients who have progressed to all three. Patients who develop none of these organ dysfunctions have a mortality rate that approaches zero. CONCLUSIONS: Central nervous system, pulmonary, and hepatic dysfunctions are intimately involved in the mortal complications of hematopoietic stem cell transplantation. Because these organ dysfunctions have similar correlates and similar outcomes, the hypothesis that they are individual parts of a systemic disorder is proposed. The additional observation that these organ dysfunctions are associated with abnormally high levels of inflammation-related cytokines raises the possibility that their pathogenesis is similar to that of multiple organ dysfunction syndrome in other populations of critically ill patients.
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Authors | William D Haire |
Journal | Critical care medicine
(Crit Care Med)
Vol. 30
Issue 5 Suppl
Pg. S257-62
(May 2002)
ISSN: 0090-3493 [Print] United States |
PMID | 12004245
(Publication Type: Journal Article, Review)
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Chemical References |
- Interleukin-6
- Protein C
- Tumor Necrosis Factor-alpha
- Antithrombin III
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Topics |
- Antithrombin III
(metabolism)
- Central Nervous System Diseases
(blood, etiology, mortality)
- Hematopoietic Stem Cell Transplantation
(adverse effects)
- Hepatic Veno-Occlusive Disease
(blood, etiology, mortality)
- Humans
- Interleukin-6
(blood)
- Logistic Models
- Lung Diseases
(blood, etiology, mortality)
- Multiple Organ Failure
(blood, etiology, mortality)
- Protein C
(metabolism)
- Tumor Necrosis Factor-alpha
(metabolism)
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