Acute basophilic leukemia lacking basophil-specific antigens: the importance of cytokine receptor expression in differential diagnosis.
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| Abstract |
De novo acute basophilic leukemia (ABL) is a rare form of myeloid leukemia. The low prevalence of ABL makes it difficult to define its clinical characteristics and to establish an effective therapeutic protocol. We present here a case of de novo ABL in a 64-year-old Japanese man. The diagnosis of ABL depended on the following: (1) metachromasia with toluidine blue stain, (2) intracytoplasmic theta granules identified by electron microscopy, and (3) findings obtained from extensive immunophenotypic analysis. Although blast cells lacked basophil-specific antigens such as CDw17, CD88, and FcepsilonRI, an expression profile of cytokine receptors including CD116 (GM-CSF receptor), CD117 (c-kit), and CD123 (IL-3 receptor alpha) helped to define the cellular lineage in our case. The patient achieved complete remission with intensive chemotherapy composed of idarubicin and cytosine arabinoside and was disease free during the following 30 months. We propose that immunophenotyping, especially focusing on cytokine receptors, is useful in diagnosing ABL.
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| Authors | Akihiko Yokohama, Norifumi Tsukamoto, Nahoko Hatsumi, Miwa Suto, Tohru Akiba, Hideki Uchiumi, Tadashi Maehara, Takafumi Matsushima, Masamitsu Karasawa, Hirokazu Murakami, Shougo Shinonome, Hirohisa Saito, Yoshihisa Nojima |
| Journal | International journal of hematology (Int J Hematol) Vol. 75 Issue 3 Pg. 309-13 (Apr 2002) ISSN: 0925-5710 [Print] Japan |
| PMID | 11999362 (Publication Type: Case Reports, Journal Article) |
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