Abstract |
We administered 2 gm/kg of intravenous gamma globulin ( IVIG) to each of five consecutive patients with Landau-Kleffner syndrome, over 4 days. We compared the 1-month baseline to that following IVIG using a severity score assessing speech, comprehension, behavior, seizures, and electroencephalography. There was a significant drop in this score after IVIG (P = 0.025). Two patients had a dramatic response to IVIG, with complete resolution of symptoms. This finding suggests that IVIG has at least some efficacy for the therapy of Landau-Kleffner syndrome.
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Authors | Mohamad A Mikati, Raya Saab, Michel N Fayad, Roula N Choueiri |
Journal | Pediatric neurology
(Pediatr Neurol)
Vol. 26
Issue 4
Pg. 298-300
(Apr 2002)
ISSN: 0887-8994 [Print] United States |
PMID | 11992758
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Immunoglobulins, Intravenous
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Topics |
- Child
- Child, Preschool
- Female
- Humans
- Immunoglobulins, Intravenous
(therapeutic use)
- Infusions, Intravenous
- Landau-Kleffner Syndrome
(drug therapy, physiopathology)
- Male
- Pilot Projects
- Prospective Studies
- Statistics, Nonparametric
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