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Efficacy of intravenous immunoglobulin in Landau-Kleffner syndrome.

Abstract
We administered 2 gm/kg of intravenous gamma globulin (IVIG) to each of five consecutive patients with Landau-Kleffner syndrome, over 4 days. We compared the 1-month baseline to that following IVIG using a severity score assessing speech, comprehension, behavior, seizures, and electroencephalography. There was a significant drop in this score after IVIG (P = 0.025). Two patients had a dramatic response to IVIG, with complete resolution of symptoms. This finding suggests that IVIG has at least some efficacy for the therapy of Landau-Kleffner syndrome.
AuthorsMohamad A Mikati, Raya Saab, Michel N Fayad, Roula N Choueiri
JournalPediatric neurology (Pediatr Neurol) Vol. 26 Issue 4 Pg. 298-300 (Apr 2002) ISSN: 0887-8994 [Print] United States
PMID11992758 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Immunoglobulins, Intravenous
Topics
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Immunoglobulins, Intravenous (therapeutic use)
  • Infusions, Intravenous
  • Landau-Kleffner Syndrome (drug therapy, physiopathology)
  • Male
  • Pilot Projects
  • Prospective Studies
  • Statistics, Nonparametric

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