Abstract | PURPOSE: The aim of this study was to develop new nonoperative strategies for the management of meconium ileus in an attempt to improve on the current unacceptable failure rate. METHODS: Mice were constipated with subcutaneous morphine injection. Each then received an enema solution ( perflubron, surfactant, Tween-80, Gastrografin, Golytely, DNase, N-Acetylcysteine, Viokase, or normal saline). After the enema solution was administered, stool output was quantitated. Histologic examination of the intestines was performed on a second group of mice that also received enemas. Finally, viscosity measurements were taken of human meconium at baseline and after variable incubation periods with each test solution. RESULTS: CONCLUSIONS:
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Authors | Mark S Burke, Jennifer M Ragi, Hratch L Karamanoukian, Martin Kotter, Guy F Brisseau, Drucey S Borowitz, Michael E Ryan, Michael S Irish, Philip L Glick |
Journal | Journal of pediatric surgery
(J Pediatr Surg)
Vol. 37
Issue 5
Pg. 760-4
(May 2002)
ISSN: 1531-5037 [Electronic] United States |
PMID | 11987095
(Publication Type: Journal Article)
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Copyright | Copyright 2002, Elsevier Science (USA). All rights reserved. |
Chemical References |
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Topics |
- Animals
- Constipation
(etiology, therapy)
- Diatrizoate Meglumine
(administration & dosage)
- Enema
(methods)
- Humans
- In Vitro Techniques
- Infant, Newborn
- Intestinal Obstruction
(complications, pathology, therapy)
- Intestines
(pathology)
- Male
- Meconium
(chemistry)
- Mice
- Viscosity
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