Abstract | BACKGROUND: METHODS: HLA class I and II antigens were typed by microdroplet lymphocyte cytotoxicity test in 33 patients with pemphigus and 100 healthy individuals. RESULTS:
HLA-B35, B44, CW4, DR4, DR14, DQ8 and DQ4 antigens were significantly high in the study group whereas HLA-DR11, DQ7 and DQ2 antigens were high among the controls. The most striking differences were observed in HLA class II antigens. HLA DR14-DQ8 and HLA B35-DR14 haplotypes were the most frequently observed ones in the study group. CONCLUSIONS: We postulate that HLA-B35, B44, CW4, DR4, DR14, DQ4 and DQ8 antigens may be responsible for susceptibility to pemphigus while HLA-DR11, DQ7 and DQ2 antigens may have a protective role in the Turkish population.
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Authors | Ahu Birol, Rana Yavuzer Anadolu, Hüseyin Tutkak, Erbak Gürgey |
Journal | International journal of dermatology
(Int J Dermatol)
Vol. 41
Issue 2
Pg. 79-83
(Feb 2002)
ISSN: 0011-9059 [Print] England |
PMID | 11982641
(Publication Type: Journal Article)
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Chemical References |
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
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Topics |
- Adult
- Aged
- Female
- Gene Frequency
(genetics)
- Genetic Predisposition to Disease
(genetics)
- Haplotypes
(genetics)
- Histocompatibility Antigens Class I
(genetics)
- Histocompatibility Antigens Class II
(genetics)
- Humans
- Linkage Disequilibrium
(genetics)
- Male
- Middle Aged
- Pemphigus
(epidemiology, genetics)
- Turkey
(epidemiology)
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