Topical ketorolac tromethamine 0.5% versus diclofenac sodium 0.1% to inhibit miosis during cataract surgery.

Abstract

PURPOSE:

To compare the effect of topical ketorolac tromethamine 0.5% solution and topical diclofenac sodium 0.1% solution on the inhibition of surgically induced miosis.

SETTING:

Tertiary care teaching hospital in South India.

METHODS:

Fifty-one patients were prospectively randomized to receive ketorolac 0.5% or diclofenac 0.1% at 3 intervals preoperatively. Patients with diabetes mellitus, pseudoexfoliation, or local pupil abnormalities were excluded from the study. Mydriatics comprising homatropine 1% plus phenylephrine 10% were instilled in all patients 1 hour before the peribulbar block at 5 intervals. Horizontal pupil diameters were obtained at the beginning of surgery, after capsulotomy, after intraocular lens (IOL) implantation, and at the end of surgery.

RESULTS:

The mean horizontal pupil diameter was 7.40 mm at the start of surgery in both groups. The ketorolac group showed a consistent trend toward larger pupil diameters at subsequent surgical intervals. Changes from baseline also indicated more significant inhibition of miosis in the ketorolac group.

CONCLUSIONS:

Topical ketorolac was a more effective inhibitor of miosis than topical diclofenac during extracapsular cataract extraction and IOL implantation. It also provided a more stable mydriatic effect throughout surgery.

• Authors: Renuka Srinivasan, Madhavaranga
• Journal: Journal of cataract and refractive surgery (J Cataract Refract Surg) Vol. 28 Issue 3 Pg. 517-20 (Mar 2002) ISSN: 0886-3350 [Print] United States
• PMID: 11973101 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Mydriatics
• Ophthalmic Solutions
• Diclofenac
• Ketorolac

Topics

• Administration, Topical
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
• Cataract Extraction (adverse effects)
• Diclofenac (administration & dosage)
• Double-Blind Method
• Humans
• Ketorolac (administration & dosage)
• Lens Implantation, Intraocular
• Miosis (etiology, prevention & control)
• Mydriatics (administration & dosage)
• Ophthalmic Solutions
• Pilot Projects
• Prospective Studies
• Pupil (drug effects)