Zolmitriptan orally disintegrating tablet is effective in the acute treatment of migraine.

Abstract

A new formulation of zolmitriptan has been developed that dissolves on the tongue without the need for additional fluid intake. In this double-blind, parallel study, 471 patients were randomized to receive the zolmitriptan orally disintegrating tablet 2.5 mg (n=231) or matching placebo (n=240) to treat a single moderate or severe migraine. Headache relief following zolmitriptan 2.5 mg (63%) was significantly greater than with placebo (22%) at 2 h post-dose (primary endpoint; P < 0.0001). The zolmitriptan orally disintegrating tablet was also significantly more effective than placebo for 1-, 2- and 4-h pain-free response (8% vs. 3%, P=0.0207, 27% vs. 7%, P < 0.0001, and 37% vs. 11%, P < 0.0001, respectively). Of those patients stating a preference, 70% of patients preferred the orally disintegrating tablet to a conventional tablet. Zolmitriptan orally disintegrating tablets are an effective and convenient alternative to a conventional tablet, allowing migraine attacks to be treated anytime a migraine strikes, which can facilitate earlier treatment.

• Authors: A J Dowson, E A MacGregor, R A Purdy, W J Becker, J Green, S L Levy
• Journal: Cephalalgia : an international journal of headache (Cephalalgia) Vol. 22 Issue 2 Pg. 101-6 (Mar 2002) ISSN: 0333-1024 [Print] England
• PMID: 11972576 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Oxazolidinones
• Serotonin Receptor Agonists
• Tryptamines
• zolmitriptan

Topics

• Administration, Oral
• Adult
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Migraine Disorders (drug therapy, physiopathology)
• Oxazolidinones (administration & dosage, adverse effects, chemistry, therapeutic use)
• Palliative Care
• Patient Satisfaction
• Recurrence
• Retreatment
• Serotonin Receptor Agonists (administration & dosage, adverse effects, chemistry, therapeutic use)
• Solubility
• Tryptamines