Treatment of disseminated granuloma annulare with a 5-lipoxygenase inhibitor and vitamin E.

Abstract

Histologically, granuloma annulare (GA) is a common non-infectious necrobiotic granulomatous reaction pattern that correlates with a number of different, but relatively specific clinical presentations. The cause or causes of GA are unknown: when localized, it is usually self-limiting, but it may be persistent when disseminated. We present three women who had had disseminated GA for more than 1 year. One patient had previously been treated with isotretinoin with no response. All three patients were treated with vitamin E 400 IU daily and zileuton 2400 mg daily. All responded within 3 months with complete clinical clearing. The anti-inflammatory and immune regulatory effects of vitamin E and zileuton may be an effective treatment in some patients with prolonged disseminated/generalized GA.

• Authors: Kathleen J Smith, C Norwood, H Skelton
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 146 Issue 4 Pg. 667-70 (Apr 2002) ISSN: 0007-0963 [Print] England
• PMID: 11966702 (Publication Type: Case Reports, Journal Article)

Chemical References

• Lipoxygenase Inhibitors
• Vitamin E
• zileuton
• Hydroxyurea

Topics

• Drug Therapy, Combination
• Female
• Follow-Up Studies
• Granuloma Annulare (drug therapy, pathology)
• Humans
• Hydroxyurea (analogs & derivatives, therapeutic use)
• Lipoxygenase Inhibitors (therapeutic use)
• Middle Aged
• Vitamin E (therapeutic use)