Remarkably enhanced inhibitory effects of three-component hybrid liposomes including sugar surfactants on the growth of lung carcinoma cells.

Abstract

Sugar parts play important roles in recognizing molecules on the cell membranes. We successfully produced sugar-type micellar surfactants, lactonoalkylamide (LacCn), for the first time. Spherical vesicles, three-component hybrid liposomes, were obtained after the sonication of the mixture of L-alpha-dimyristoyl-phosphatidylcholine (DMPC), Tween 20 and LacCn (DMPC:Tween 20:LacCn=65:7:28). It is noteworthy that high inhibitory effects of the three-component hybrid liposomes composed of DMPC, Tween 20, and LacCn (DMPC:Tween 20:LacCn=65:7:28) on the growth of glioma (U251) and lung adenocarcinoma (RERF-LC-OK) cells were attained in vitro without any drug, although no significant inhibitory effects of any individual component (DMPC, Tween 20, LacCn) or the two-component hybrid liposomes of DMPC and Tween 20 on the growth of tumor cells examined were obtained.

• Authors: Ryuichi Ueoka, Yoko Matsumoto, Shigeru Hirose, Koichi Goto, Masahiro Goto, Shintaro Furusaki
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 50 Issue 4 Pg. 563-5 (Apr 2002) ISSN: 0009-2363 [Print] Japan
• PMID: 11964013 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amides
• Antineoplastic Agents
• Lactones
• Liposomes
• Polysorbates
• Surface-Active Agents
• Dimyristoylphosphatidylcholine

Topics

• Adenocarcinoma (pathology)
• Amides (chemistry, pharmacology)
• Animals
• Antineoplastic Agents (chemistry, pharmacology, toxicity)
• Body Weight (drug effects)
• Cell Division (drug effects)
• Dimyristoylphosphatidylcholine (chemistry, pharmacology, toxicity)
• Glioma (pathology)
• Humans
• Lactones (pharmacology, toxicity)
• Liposomes
• Lung Neoplasms (pathology)
• Mice
• Organ Size (drug effects)
• Polysorbates (chemistry, pharmacology, toxicity)
• Surface-Active Agents (chemistry, pharmacology, toxicity)
• Tumor Cells, Cultured