Abstract |
This study determined fluoride (F) concentrations in whole saliva and dental plaque after intake of fluoridated milk using a randomised crossover experimental design. Eighteen healthy children (6-8 years) were subjected to each of four different 3-day drinking regimens: (a) 200 ml F-free tap water; (b) 200 ml tap water with 1.0 mg F; (c) 200 ml standard milk, and (d) 200 ml standard milk with 1.0 mg F. A washout period of 7 days was organised between the different drinking regimens. All children used F-free toothpaste prior to and during the trial and were instructed to avoid F-rich food and drinks. F concentration in unstimulated whole saliva was determined at baseline and after 15 and 120 min and in plaque samples at baseline and after 2 h. The mean baseline values ranged from 0.01 to 0.02 mg F/l in saliva and between 10.4 and 14.2 mg F/l in dental plaque. A statistically significant (p < 0.05) increase of F was disclosed in saliva 15 min after drinking F-containing milk and water (0.052 and 0.058 mg F/l, respectively). After 2 h, the salivary F(-) concentrations were back to baseline values. In the plaque, however, a statistically significant (p < 0.01) twofold increase was found at 2 h after the intake of fluoridated milk and water, respectively. The results indicate that consumption of fluoridated milk contributes to a F storing process with significantly elevated F concentrations in dental plaque up to 2 h after intake. Further studies are required to determine the 'therapeutic concentration' of F in dental plaque after intake of fluoridated milk.
|
Authors | L G Petersson, I Arvidsson, E Lynch, K Engström, S Twetman |
Journal | Caries research
(Caries Res)
2002 Jan-Feb
Vol. 36
Issue 1
Pg. 40-3
ISSN: 0008-6568 [Print] Switzerland |
PMID | 11961329
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright 2002 S. Karger AG, Basel |
Chemical References |
- Cariostatic Agents
- Toothpastes
- Water
- Fluorides
|
Topics |
- Animals
- Cariostatic Agents
(administration & dosage, analysis, therapeutic use)
- Child
- Cross-Over Studies
- Dental Plaque
(chemistry)
- Drinking
- Female
- Fluorides
(administration & dosage, analysis, therapeutic use)
- Follow-Up Studies
- Humans
- Ion-Selective Electrodes
- Male
- Milk
- Saliva
(chemistry)
- Statistics as Topic
- Toothpastes
(therapeutic use)
- Water
|