Abstract |
A potential model for bipolar disorder, quinpirole-induced biphasic locomotion, was used for a preliminary evaluation of behavioral effects of oral anticonvulsant treatment. Quinpirole, a D2/D3 agonist, induces a biphasic locomotor response starting with inhibition and followed by excitation, resembling the oscillating nature of bipolar disorder. The present study developed a paradigm for oral administration of anticonvulsants that resulted in therapeutic blood levels and tested the effects of treatment on the quinpirole-induced response. Eleven days treatment with valproate (12 g/liter water), phenytoin (6 g/kg food), and carbamazepine (8 g/kg food) resulted in therapeutic blood levels and in a borderline significant reduction in quinpirole-induced hyperactivity without effects on the hypoactive phase. Valproate effects became more significant at the height of the hyperactivity response. Eleven days treatment with topiramate (30 mg/kg) resulted in a significant attenuation of quinpirole-induced hyperactivity, qualitatively similar to the effects of the other anticonvulsants. The results suggest that mood-stabilizing anticonvulsant drugs including topiramate may attenuate quinpirole-induced hyperactivity.
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Authors | A Shaldubina, H Einat, H Szechtman, H Shimon, R H Belmaker |
Journal | Journal of neural transmission (Vienna, Austria : 1996)
(J Neural Transm (Vienna))
Vol. 109
Issue 3
Pg. 433-40
(Mar 2002)
ISSN: 0300-9564 [Print] Austria |
PMID | 11956963
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticonvulsants
- Dopamine Agonists
- Receptors, Dopamine
- Topiramate
- Quinpirole
- Fructose
- Carbamazepine
- Valproic Acid
- Phenytoin
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Topics |
- Administration, Oral
- Animals
- Anticonvulsants
(pharmacology)
- Bipolar Disorder
(chemically induced, drug therapy, physiopathology)
- Brain
(drug effects, metabolism, physiopathology)
- Carbamazepine
(blood, pharmacology)
- Disease Models, Animal
- Dopamine Agonists
(pharmacology)
- Drug Administration Schedule
- Fructose
(analogs & derivatives, pharmacology)
- Hyperkinesis
(chemically induced, drug therapy, physiopathology)
- Motor Activity
(drug effects, physiology)
- Neurons
(drug effects, metabolism)
- Phenytoin
(blood, pharmacology)
- Quinpirole
(pharmacology)
- Rats
- Receptors, Dopamine
(drug effects, metabolism)
- Topiramate
- Valproic Acid
(blood, pharmacology)
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