Beneficial effects of tandospirone on ataxia of a patient with Machado-Joseph disease.

Abstract

Tandospirone citrate (tandospirone) is an anti-anxiety drug that acts by combining with serotonin receptor (5-hydroxytryptamine-1 A [5-HT1A]). Recently, there have been a few reports of its potential role in the treatment of cerebellar ataxia. We report the first case of a patient with Machado-Joseph disease in which we successfully treated cerebellar ataxia. In addition, his leg pain, insomnia, anorexia, and depression, which are thought to be related to 5-HT1A receptors, were also remarkably alleviated by treatment with tandospirone.

• Authors: Asako Takei, Sanae Honma, Atushi Kawashima, Ichiro Yabe, Toshiyuki Fukazawa, Keiko Hamada, Takeshi Hamada, Kunio Tashiro
• Journal: Psychiatry and clinical neurosciences (Psychiatry Clin Neurosci) Vol. 56 Issue 2 Pg. 181-5 (Apr 2002) ISSN: 1323-1316 [Print] Australia
• PMID: 11952922 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Anxiety Agents
• Isoindoles
• Piperazines
• Pyrimidines
• Receptors, Serotonin
• Receptors, Serotonin, 5-HT1
• tandospirone

Topics

• Anti-Anxiety Agents (administration & dosage, pharmacology)
• Cerebellar Ataxia (drug therapy, etiology)
• Humans
• Isoindoles
• Machado-Joseph Disease (complications)
• Male
• Middle Aged
• Piperazines (administration & dosage, pharmacology)
• Pyrimidines (administration & dosage, pharmacology)
• Receptors, Serotonin (drug effects, physiology)
• Receptors, Serotonin, 5-HT1
• Treatment Outcome