Abstract | OBJECTIVE:
Amblyopia consists of reduced visual function in the absence of organic disease, caused by deficient visual stimulation, most commonly due to squint or refractive error. Amblyopia is thought to be reversible up until the age of approximately 8 years (critical period) and is usually treated with occlusion of the fellow eye. There is recent evidence for visual system plasticity extending beyond the critical period, supported by reports of improvement in visual acuity in the amblyopic eye after loss of vision in the contralateral eye. This suggests that the adult visual system exhibits sufficient plasticity to allow such improvement. We describe here improvement in visual acuity in three amblyopic patients after they received high-dose intravenous glucocorticoids for optic neuritis in the contralateral eye. METHODS: Clinical and neurological evaluation added. RESULTS: In all cases, the improvement was sustained, even after the recovery from the optic neuritis. CONCLUSIONS: Because steroids affect neural plasticity, we hypothesize that they facilitate and enhance visual improvement in amblyopia, a quality that may be tested in future controlled trials.
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Authors | C S Constantinescu, I Gottlob |
Journal | Neurorehabilitation and neural repair
(Neurorehabil Neural Repair)
Vol. 15
Issue 3
Pg. 223-7
( 2001)
ISSN: 1545-9683 [Print] United States |
PMID | 11944744
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adult
- Amblyopia
(complications, drug therapy)
- Female
- Glucocorticoids
(therapeutic use)
- Humans
- Neuronal Plasticity
(drug effects)
- Optic Neuritis
(complications, drug therapy)
- Visual Acuity
(drug effects)
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