[The effects of BDP on calcium ion in the granular leukocytes in nasal secretions of the patients with allergic rhinitis].

Abstract

OBJECTIVE:

To study the effects of beclomethasone dipropionate (BDP) on the inflammatory granular leukocytes in nasal secretions of the patients with allergic rhinitis.

METHOD:

The change of intercellular calcium ion of the eosinophils and neutrophils in the nasal secretions were observed under the laser scanning confocal microscopy and technology of fluorescence.

RESULT:

The concentration of intercellular calcium ion either in eosinophils or in neutrophils significantly rose after BDP treatment.

CONCLUSION:

BDP can rise the concentration of intercellular calcium ion in the granular leukocytes, which may be a factor of the anti-inflammation functions of BDP.

• Authors: Zhizhong Shen, Hao Wang, Huige Wang, Juelong Lin, Yaowen Chen, Dehui Song
• Journal: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology (Lin Chuang Er Bi Yan Hou Ke Za Zhi) Vol. 16 Issue 1 Pg. 25-6 (Jan 2002) China
• PMID: 11944477 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Beclomethasone
• Calcium

Topics

• Anti-Inflammatory Agents (pharmacology)
• Beclomethasone (pharmacology)
• Calcium (metabolism)
• Cells, Cultured
• Eosinophils (drug effects, metabolism)
• Humans
• Nasal Mucosa (metabolism)
• Neutrophils (drug effects, metabolism)
• Rhinitis, Allergic, Perennial (drug therapy)