Abstract | CONTEXT: Short-contact application of 0.1% tazarotene gel for acne was devised to minimize local adverse effects. Its efficacy and safety are unknown. OBJECTIVES: To assess acne improvement and tolerability during 12 weeks of short-contact treatment with 0.1% tazarotene gel vs a nonmedicated gel control. DESIGN: A randomized, masked, vehicle-controlled trial. SETTING: Outpatient facilities at an urban medical school and an affiliated suburban office practice. PARTICIPANTS: Ninety-nine volunteers with facial acne were enrolled; 81 completed the study. INTERVENTION: Thirty-three patients were randomly assigned to each of 3 groups: T + T applied 0.1% tazarotene gel twice daily, T + V applied 0.1% tazarotene gel once daily and vehicle gel once daily, and V + V applied vehicle gel twice daily. Patients adjusted the contact period as tolerated, between 30 seconds and 5 minutes per application. MAIN OUTCOME MEASURES:
Acne efficacy by reduction in acne lesions, treatment success (50%-100% improvement in global response to treatment) and improvement in overall disease severity. Local adverse effects, scored from none to severe. RESULTS: By week 12, T + T and T + V achieved significantly greater improvement in acne than V + V based on mean percentage reduction in noninflammatory lesions (46% and 41% vs 2%; P =.002) and inflammatory lesions (38% and 34% vs 9%; P =.01), percentage of treatment successes (64% and 61% vs 15%; P<.001), and reduction in overall disease severity (30% and 29% vs 3%; P<.001). Local adverse effects did not differ significantly among the 3 groups after week 4. CONCLUSION:
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Authors | Susan Bershad, Giselle Kranjac Singer, Janice E Parente, Mei-Heng Tan, Daniel W Sherer, Andrea N Persaud, Mark Lebwohl |
Journal | Archives of dermatology
(Arch Dermatol)
Vol. 138
Issue 4
Pg. 481-9
(Apr 2002)
ISSN: 0003-987X [Print] United States |
PMID | 11939810
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Gels
- Nicotinic Acids
- Retinoids
- tazarotene
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Topics |
- Acne Vulgaris
(drug therapy)
- Adolescent
- Adult
- Child
- Female
- Gels
- Humans
- Male
- Nicotinic Acids
(administration & dosage)
- Remission Induction
- Retinoids
(administration & dosage)
- Time Factors
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