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Anti-LM1 antibodies in the sera of patients with Guillain-Barré syndrome, Miller Fisher syndrome, and motor neuron disease.

Abstract
This study is designed to establish whether sialosylneolactotetraosylceramide (LM1), a major component of human peripheral nerve ganglioside, is a potential target antigen for the development of peripheral autoimmune neuropathies such as Guillain-Barré syndrome (GBS) and Miller Fisher syndrome (MFS). Serum antibodies against LM1 in 116 patients with GBS, 56 patients with MFS, 88 patients with motor neuron disease (MND) and 60 normal control subjects were quantified using enzyme-linked immunosorbent assay (ELISA). The presence of anti-LM1 antibodies were confirmed using an immunostaining method on high-performance thin-layer chromatographic plates (HPTLC). Anti-LM1 IgG antibodies were detected in 22% (25/116) of patients with GBS. The ratio of the demyelination type to the axonal type of GBS was approximately 3:1. Among the 25 anti-LM1-positive GBS patients, additional anti-GM1 IgG antibodies were detected in 7 patients, 4 of whom possessed the axonal form of GBS. Anti-LM1 antibodies were also detected in a significant portion of patients with MFS (20%, 11/56). In contrast, anti-LM1 antibodies were detected in only 2% (2/88) of patients with MND, and 7% (4/60) of normal control subjects. The results of this study suggest that serum antibodies against LM1 may have a pathogenic role in the development of GBS and MFS.
AuthorsHajime Harukawa, Hiroya Utsumi, Atsuko Asano, Hiide Yoshino
JournalJournal of the peripheral nervous system : JPNS (J Peripher Nerv Syst) Vol. 7 Issue 1 Pg. 54-8 (Mar 2002) ISSN: 1085-9489 [Print] United States
PMID11939352 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Autoantibodies
  • Biomarkers
  • Gangliosides
  • LM1 ganglioside
Topics
  • Autoantibodies (blood)
  • Biomarkers
  • Chromatography, Thin Layer
  • Enzyme-Linked Immunosorbent Assay
  • Gangliosides (immunology)
  • Humans
  • Miller Fisher Syndrome (immunology)
  • Motor Neuron Disease (immunology)

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