Abstract | BACKGROUND: Most patients with pancreatic cancer are not candidates for curative resection. The goal of this study was to evaluate the safety of an intraoperative ultrasound-guided cryosurgical procedure in a phase I study of unresectable pancreatic cancer. METHODS: From March 1995 to March 1999, 10 cryosurgeries using intraoperative ultrasound were performed on 9 patients with unresectable cancers at laparotomy. Four patients had a concurrent gastrojejunostomy, 2 had a chemical splanchnicectomy, and 1 underwent a concurrent hepatic cryosurgical procedure. RESULTS: There was no intraoperative morbidity or mortality. No patients developed postoperative pancreatitis or fistula. All patients had good pain control postoperatively and were tolerating a regular diet at the time of discharge. Pain control at discharge was achieved with an oral formulation (4/9), transdermal patch (3/9), no pain medication (1/9), and intravenous patient controlled analgesia (1/9). CONCLUSIONS:
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Authors | Stephen J Kovach, Richard J Hendrickson, Charles R Cappadona, C Max Schmidt, Kara Groen, Leonidas G Koniaris, James V Sitzmann |
Journal | Surgery
(Surgery)
Vol. 131
Issue 4
Pg. 463-4
(Apr 2002)
ISSN: 0039-6060 [Print] United States |
PMID | 11935137
(Publication Type: Clinical Trial, Clinical Trial, Phase I, Journal Article)
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Topics |
- Cryosurgery
(methods)
- Denervation
- Gastrostomy
- Humans
- Intraoperative Period
- Jejunostomy
- Palliative Care
- Pancreatic Neoplasms
(diagnostic imaging, surgery)
- Postoperative Care
- Prospective Studies
- Splanchnic Nerves
- Treatment Outcome
- Ultrasonography
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