[Genetic polymorphism analysis of apolipoprotein CII microsatellite DNA (TG) n (AG) m in patients with coronary heart disease].

Abstract

OBJECTIVE:

To investigate the relationship between the polymorphism of apolipoprotein CII (apoCII) microsatellite DNA (TG) n (AG) m and coronary heart disease (CHD).

METHODS:

The apoCII microsatellite DNA (TG) n(AG)m genotypes of 108 patients with CHD and 231 healthy persons were detected by using polymerase chain reaction (PCR) and high voltage denatured polyacrylamid gels electrophoresis.

RESULTS:

The allele frequency distribution was significantly different between controls and patients with CHD (chi 2 = 19.93, P < 0.05). The allele 17 frequency in CHD group was remarkably higher than that in controls (chi 2 = 13.98, P < 0.01). The concentrations of TG and HDL-C among different genotype groups were significantly different. The levels of TG in 17/29 group and 17/30 group were higher than those in other groups (P < 0.05), while the concentration of HDL-C was lower (P < 0.05).

CONCLUSION:

The allele 17 of apoCII may be an independent risk factor for CHD in Han population.

• Authors: C Gao, X Zhou, Z Yin
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 81 Issue 23 Pg. 1436-8 (Dec 10 2001) ISSN: 0376-2491 [Print] China
• PMID: 11930616 (Publication Type: English Abstract, Journal Article)

Chemical References

• Apolipoprotein A-I
• Apolipoprotein C-II
• Apolipoproteins B
• Apolipoproteins C
• Cholesterol, HDL
• Cholesterol, LDL
• DNA

Topics

• Adult
• Aged
• Apolipoprotein A-I (blood)
• Apolipoprotein C-II
• Apolipoproteins B (blood)
• Apolipoproteins C (genetics)
• Base Sequence
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Coronary Disease (blood, genetics)
• DNA (chemistry, genetics)
• Female
• Gene Frequency
• Genotype
• Humans
• Male
• Microsatellite Repeats (genetics)
• Middle Aged
• Molecular Sequence Data
• Polymorphism, Genetic
• Sequence Analysis, DNA