Abstract | BACKGROUND: METHODS AND RESULTS: We studied 20 consecutive patients in whom coronary artery spasm was provoked by intracoronary ACh. The patients underwent a second ACh challenge after pretreatment with intracoronary saline (n=5) or fasudil (n=15; 300 microg/min for 15 minutes). Angina and coronary vasospasm were reproducibly induced by the second testing in patients who received saline. In contrast, fasudil markedly attenuated the coronary constriction induced by ACh (P<0.001) and prevented the occurrence of chest pain and ischemic ECG changes in all treated patients (both P<0.01 versus saline). Fasudil, at the dose used in this study, did not significantly change systemic hemodynamics or baseline coronary blood flow. CONCLUSIONS:
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Authors | Akihiro Masumoto, Masahiro Mohri, Hiroaki Shimokawa, Lemmy Urakami, Makoto Usui, Akira Takeshita |
Journal | Circulation
(Circulation)
Vol. 105
Issue 13
Pg. 1545-7
(Apr 02 2002)
ISSN: 1524-4539 [Electronic] United States |
PMID | 11927519
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Enzyme Inhibitors
- Intracellular Signaling Peptides and Proteins
- Vasoconstrictor Agents
- 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
- Protein Serine-Threonine Kinases
- rho-Associated Kinases
- Acetylcholine
- fasudil
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Topics |
- 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
(analogs & derivatives, pharmacology)
- Acetylcholine
(pharmacology)
- Aged
- Angina, Unstable
(diagnostic imaging, enzymology, physiopathology)
- Coronary Angiography
- Coronary Vasospasm
(prevention & control)
- Coronary Vessels
(drug effects, enzymology, physiopathology)
- Enzyme Inhibitors
(pharmacology)
- Female
- Humans
- Intracellular Signaling Peptides and Proteins
- Male
- Middle Aged
- Protein Serine-Threonine Kinases
(antagonists & inhibitors)
- Vasoconstriction
(drug effects)
- Vasoconstrictor Agents
(pharmacology)
- rho-Associated Kinases
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