Abstract |
The efficacy of a novel, proprietary topical formulation of ibuprofen 5% gel (Ibugel) was evaluated in a placebo-controlled study in patients with soft tissue injuries. Patients received either active gel (n=40) or placebo gel (n=41) for a maximum of seven days. Pain and interference with physical activity were assessed daily using visual analogue scales. There was a significant difference (p<0.001) in favour of active treatment for the time to achieve clinically meaningful reduction in pain. By day 7, 75% of patients in the active gel group had a clinically meaningful reduction of pain compared with 39% of patients who received placebo. Despite differences between study centres, the data for interference with physical activity also showed an advantage for active treatment. By day 7, 79% of patients in the active gel group had a clinically meaningful reduction in interference with physical activity, compared with 44% of patients who received placebo.
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Authors | J Machen, M Whitefield |
Journal | International journal of clinical practice
(Int J Clin Pract)
Vol. 56
Issue 2
Pg. 102-6
(Mar 2002)
ISSN: 1368-5031 [Print] India |
PMID | 11926695
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Gels
- Ibuprofen
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Topics |
- Administration, Topical
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage)
- Double-Blind Method
- Female
- Gels
- Humans
- Ibuprofen
(administration & dosage)
- Male
- Middle Aged
- Pain
(drug therapy)
- Soft Tissue Injuries
(drug therapy)
- Treatment Outcome
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