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Efficacy of a proprietary ibuprofen gel in soft tissue injuries: a randomised, double-blind, placebo-controlled study.

Abstract
The efficacy of a novel, proprietary topical formulation of ibuprofen 5% gel (Ibugel) was evaluated in a placebo-controlled study in patients with soft tissue injuries. Patients received either active gel (n=40) or placebo gel (n=41) for a maximum of seven days. Pain and interference with physical activity were assessed daily using visual analogue scales. There was a significant difference (p<0.001) in favour of active treatment for the time to achieve clinically meaningful reduction in pain. By day 7, 75% of patients in the active gel group had a clinically meaningful reduction of pain compared with 39% of patients who received placebo. Despite differences between study centres, the data for interference with physical activity also showed an advantage for active treatment. By day 7, 79% of patients in the active gel group had a clinically meaningful reduction in interference with physical activity, compared with 44% of patients who received placebo.
AuthorsJ Machen, M Whitefield
JournalInternational journal of clinical practice (Int J Clin Pract) Vol. 56 Issue 2 Pg. 102-6 (Mar 2002) ISSN: 1368-5031 [Print] India
PMID11926695 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Gels
  • Ibuprofen
Topics
  • Administration, Topical
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
  • Double-Blind Method
  • Female
  • Gels
  • Humans
  • Ibuprofen (administration & dosage)
  • Male
  • Middle Aged
  • Pain (drug therapy)
  • Soft Tissue Injuries (drug therapy)
  • Treatment Outcome

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