Association study between a novel single nucleotide polymorphism of the promoter region of the prostacyclin synthase gene and essential hypertension.

Abstract

The purpose of this study was to investigate whether an association exists between the promoter region of the prostacyclin synthase gene and essential hypertension (EH). Using the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) method, we discovered a novel single nucleotide polymorphism (SNP), T-192G, in the 5'-flanking region. We performed an association study using the SNP in 200 patients and 200 controls. The allele frequency distribution in the two groups was not significantly different. Thus, this SNP in the PGIS gene is not associated with EH.

• Authors: Tomohiro Nakayama, Masayoshi Soma, Dolkun Rahmutula, Hideko Tobe, Mikano Sato, Jiro Uwabo, Noriko Aoi, Kotoko Kosuge, Masako Kunimoto, Katsuo Kanmatsuse, Shinichiro Kokubun
• Journal: Hypertension research : official journal of the Japanese Society of Hypertension (Hypertens Res) Vol. 25 Issue 1 Pg. 65-8 (Jan 2002) ISSN: 0916-9636 [Print] England
• PMID: 11924728 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cytochrome P-450 Enzyme System
• Intramolecular Oxidoreductases
• prostacyclin synthetase

Topics

• Adult
• Alleles
• Base Sequence (genetics)
• Cytochrome P-450 Enzyme System (genetics)
• Female
• Gene Frequency
• Genetic Linkage
• Genotype
• Humans
• Hypertension (genetics)
• Intramolecular Oxidoreductases (genetics)
• Male
• Middle Aged
• Molecular Sequence Data
• Polymerase Chain Reaction
• Polymorphism, Genetic (genetics)
• Polymorphism, Single-Stranded Conformational
• Promoter Regions, Genetic (genetics)
• Reference Values
• Tandem Repeat Sequences