Abstract | OBJECTIVES: The purpose of the study was to test the hypothesis that intracoronary aqueous oxygen (AO) hyperbaric reperfusion reduces myocardial injury after prolonged coronary occlusion. Background. Attenuation of ischemia/reperfusion injury by the use of hyperbaric oxygen (HBO) administered during reperfusion has been demonstrated for a wide variety of tissues, including myocardium. We have recently developed a more practical, catheter-based, site-specific method for delivery of oxygen at hyperbaric levels with aqueous oxygen infusion. METHODS: Following a 60-minute balloon occlusion of the left anterior descending coronary artery in swine, intracoronary AO hyperoxemic perfusion (50 mL blood/minute; 1.5 mL AO/minute; mean pO2 = 834 104 mmHg) was performed for 90 minutes after a 15-minute period of normoxemic autoreperfusion (physiologic reperfusion). Control groups consisted of autoreperfusion alone; active normoxemic perfusion (50 mL/minute) for 90 minutes; and hyperoxemic perfusion with a hollow fiber oxygenator (HFO) for 90 minutes. Results. A significant improvement in left ventricular ejection fraction was noted by ventriculography at 105 minutes of reperfusion (ANOVA, p < 0.05), compared to the 15-minute autoreperfusion period, only in the AO and HFO groups. Mean percent infarct size (area of necrosis)/(area at risk), quantitative post-mortem hemorrhage score, and myocardial myeloperoxidase levels at 3 hours of reperfusion were significantly less in the AO group (ANOVA, p < 0.05), but not in the HFO group, compared to normoxemic groups. Conclusions. The results demonstrate that intracoronary hyperbaric reperfusion with AO, but not with a membrane oxygenator, attenuates myocardial ischemia/ reperfusion injury.
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Authors | J Richard Spears, Cassandra Henney, Petar Prcevski, Rui Xu, Li Li, Giles J Brereton, Marcello DiCarli, Ali Spanta, Richard Crilly, Abdulbaset M Sulaiman, Samir Hadeed, Steven Lavine, William R Patterson, Jeffrey Creech, Richard Vander Heide |
Journal | The Journal of invasive cardiology
(J Invasive Cardiol)
Vol. 14
Issue 4
Pg. 160-6
(Apr 2002)
ISSN: 1042-3931 [Print] United States |
PMID | 11923566
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Topics |
- Analysis of Variance
- Animals
- Hyperbaric Oxygenation
(methods)
- Infusions, Intra-Arterial
- Models, Animal
- Myocardial Infarction
(therapy)
- Myocardial Reperfusion
(methods)
- Myocardial Reperfusion Injury
(prevention & control)
- Swine
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