Abstract | STUDY OBJECTIVE: METHODS: Rats were prospectively randomized to either a control (n=45), low-dose Carbicarb (LDC; 3 mL/kg, n=45), or high-dose Carbicarb (HDC; 6 mL/kg, n=45) group in a blinded fashion during resuscitation after 8 minutes of asphyxial cardiac arrest. Microdialysis was used to assess brain pH and glutamate. A neurologic deficit score and neuronal cell death in the hippocampus were determined at day 7. RESULTS:
Resuscitation was greatest in LDC rats (42/45) and least in HDC rats (28/45) versus that in control rats (34/45). Brain pH was higher in the LDC and HDC rats 10 minutes after resuscitation and remained higher than that of control rats for 120 minutes after resuscitation. Glutamate levels at 10 to 120 minutes after reperfusion were lowest in the LDC rats. LDC rats had the lowest neurologic deficit score (1+/-2) versus that of control rats (13+/-8) and HDC rats (19+/-6). Hippocampal neuronal cell death was lowest in LDC rats (30+/-20) versus that in control rats (86+/-47) and HDC rats (233+/-85). CONCLUSION:
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Authors | Laurence M Katz, Yuanfan Wang, Steve Rockoff, Thomas W Bouldin |
Journal | Annals of emergency medicine
(Ann Emerg Med)
Vol. 39
Issue 4
Pg. 359-65
(Apr 2002)
ISSN: 0196-0644 [Print] United States |
PMID | 11919521
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carbonates
- Drug Combinations
- sodium bicarbonate, sodium carbonate drug combination
- Glutamic Acid
- Sodium Bicarbonate
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Topics |
- Acidosis
(drug therapy, etiology)
- Animals
- Asphyxia
(complications)
- Brain
(metabolism)
- Brain Ischemia
(drug therapy, etiology, metabolism)
- Carbonates
(therapeutic use)
- Cell Death
(drug effects)
- Disease Models, Animal
- Drug Combinations
- Glutamic Acid
(drug effects, metabolism)
- Heart Arrest
(complications)
- Hippocampus
(metabolism)
- Neurons
(drug effects)
- Rats
- Recovery of Function
(drug effects)
- Reperfusion Injury
(drug therapy, etiology)
- Sodium Bicarbonate
(therapeutic use)
- Treatment Outcome
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