Abstract | BACKGROUND: OBJECTIVE: The aim of this study was to determine whether iron supplementation in goitrous, iron-deficient children would improve their response to iodized salt. DESIGN: We conducted a randomized, double-blind, placebo-controlled trial in 5-14-y-old children in Côte d'Ivoire. Goitrous, iron-deficient children (n = 166) consuming iodized salt (10-30 mg I/kg salt at the household level) were supplemented with either iron (60 mg Fe/d, 4 d/wk for 16 wk) or placebo. At 0, 1, 6, 12, and 20 wk, we measured hemoglobin, serum ferritin, serum transferrin receptor, whole-blood zinc protoporphyrin, thyrotropin, thyroxine, urinary iodine, and thyroid gland volume (by ultrasonography). RESULTS:
Hemoglobin and iron status at 20 wk were significantly better after iron treatment than after placebo (P < 0.05). At 20 wk, the mean reduction in thyroid size in the iron-treated group was nearly twice that in the placebo group (x +/- SD percentage change in thyroid volume from baseline: -22.8 +/- 10.7% compared with -12.7 +/- 10.1%; P < 0.01). At 20 wk, goiter prevalence was 43% in the iron-treated group compared with 62% in the placebo group (P < 0.02). There were no significant differences between groups in whole-blood thyrotropin or serum thyroxine at baseline or during the intervention. CONCLUSIONS:
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Authors | Sonja Y Hess, Michael B Zimmermann, Pierre Adou, Toni Torresani, Richard F Hurrell |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 75
Issue 4
Pg. 743-8
(Apr 2002)
ISSN: 0002-9165 [Print] United States |
PMID | 11916762
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hemoglobins
- Sodium Chloride, Dietary
- iodized salt
- Thyrotropin
- Iodine
- Iron
- Thyroxine
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Topics |
- Adolescent
- Anemia, Iron-Deficiency
(complications, drug therapy, epidemiology)
- Child
- Child, Preschool
- Cote d'Ivoire
(epidemiology)
- Double-Blind Method
- Female
- Goiter, Endemic
(complications, drug therapy, epidemiology)
- Hemoglobins
(drug effects)
- Humans
- Iodine
(therapeutic use)
- Iron
(therapeutic use)
- Male
- Prevalence
- Sodium Chloride, Dietary
(therapeutic use)
- Thyrotropin
(blood)
- Thyroxine
(blood)
- Treatment Outcome
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