Abstract | OBJECTIVE: METHODS: RESULTS: Supine blood pressure was 172 +/- 8.8/89 +/- 6.1 mmHg before ganglionic blockade. Blood pressure decreased 47 +/- 5/18 +/- 3 mmHg with trimethaphan (16 +/- 4.4/4 +/- 4.0 mmHg in autosomal-dominant hypertension, P < 0.05). Before ganglionic blockade, 25 microg phenylephrine increased systolic blood pressure 17 +/- 4 mmHg in patients with essential hypertension and 30 +/- 3 mmHg in patients with autosomal-dominant hypertension (P < 0.05). During ganglionic blockade, the same dose increased systolic blood pressure 32 +/- 1 and 33 +/- 4 mmHg in patients with essential and with autosomal-dominant hypertension, respectively (NS). CONCLUSIONS:
Phenylephrine hypersensitivity due to baroreflex dysfunction is uncommon in patients with essential hypertension and NVC. This finding may suggest that the effect of NVC on autonomic regulation is heterogeneous. An alternative explanation is that radiological NVC is not necessarily functionally relevant.
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Authors | Jens Jordan, Jens Tank, Hennriette Hohenbleicher, Hakan Toka, Christoph Schröder, Arya M Sharma, Friedrich C Luft |
Journal | Journal of hypertension
(J Hypertens)
Vol. 20
Issue 4
Pg. 701-6
(Apr 2002)
ISSN: 0263-6352 [Print] England |
PMID | 11910306
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antihypertensive Agents
- Ganglionic Blockers
- Phenylephrine
- Trimethaphan
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Topics |
- Antihypertensive Agents
(pharmacology)
- Autonomic Nervous System
(physiopathology)
- Baroreflex
(drug effects, physiology)
- Blood Pressure
(drug effects)
- Brain Stem
(physiopathology)
- Cerebellum
(blood supply)
- Drug Resistance
- Female
- Ganglionic Blockers
(pharmacology)
- Humans
- Hypertension
(drug therapy, genetics, physiopathology)
- Male
- Medulla Oblongata
(physiopathology)
- Middle Aged
- Models, Cardiovascular
- Models, Neurological
- Phenylephrine
(pharmacology)
- Trimethaphan
(pharmacology)
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