Cyclooxygenase (COX)-2 inhibitors have been developed with the goal of providing similar efficacy and greater safety compared with traditional nonsteroidal anti-inflammatory drugs. Development was based on the hypothesis that COX-1 is the housekeeping
enzyme necessary for production of
prostaglandins (PGs) with homeostatic functions, whereas COX-2 is a mediator of pathophysiologic processes. However, later research has demonstrated a role of COX-2 in production of PGs that have functions under normal physiologic conditions. In the vasculature, COX-2 seems to be the main
enzyme responsible for the production of
prostacyclin. Increased synthesis of this vasodilatory and antithrombotic PG represents a homeostatic response during periods of accelerated platelet-vessel wall interactions and counteracts increased synthesis of COX-1-derived prothrombotic
prostanoid thromboxane A(2) (TXA(2)). The clinical sequelae of inhibiting
prostacyclin activity in the absence of concomitant inhibition of TXA(2) are not currently clear. Animal studies show that inhibition of
prostacyclin activity does not lead to spontaneous
thrombosis but may increase response to thrombotic stimuli. Therefore,
prostacyclin synthesis may be important for limiting thrombotic events in patients who are at an increased cardiovascular risk. Overviews of clinical studies in
arthritis and
Alzheimer's disease have not demonstrated increased cardiovascular risk associated with specific COX-2 inhibition in most patients. However, data from 1 clinical trial revealed a 5-fold divergence in rates of
myocardial infarction between a
coxib and a nonsteroidal anti-inflammatory
drug comparitor. Credible explanations for the results of this trial have been proposed and further studies are necessary to clarify the relative risk-to-benefit ratio of COX-2 inhibition in patients at increased risk for cardiovascular events, and the effects of concomitant
aspirin therapy.