Evaluation of vaccines for atrophic rhinitis--a comparison of three challenge models.

Abstract

We compared three challenge models for the assessment of atrophic rhinitis (AR) vaccines: combined infection with Bordetella bronchiseptica (Bb) and Pasteurella multocida (Pm); application of acetic acid (AA) to the nasal mucosa followed by Pm infection; and Bb infection alone. Two vaccines were tested using standardized criteria, notably nasal lesion scores. The vaccines provided different levels of protection in the Bb and the AA/Pm challenges, but were similar in the combined (Bb/Pm) challenge. It is clear that the AA/Pm model shows the protective value of only the Pm component, whereas the single Bb challenge reflects the protective value merely of the Bb component of a combined vaccine. These results suggest that the best assessment of protection is provided if the two specific challenges are performed separately.

• Authors: T Magyar, V L King, F Kovács
• Journal: Vaccine (Vaccine) Vol. 20 Issue 13-14 Pg. 1797-802 (Mar 15 2002) ISSN: 0264-410X [Print] Netherlands
• PMID: 11906767 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Bacterial
• Bacterial Vaccines
• Vaccines, Combined
• Acetic Acid

Topics

• Acetic Acid (administration & dosage)
• Administration, Intranasal
• Animals
• Antibodies, Bacterial (blood)
• Bacterial Vaccines (administration & dosage)
• Bordetella Infections (immunology, prevention & control, veterinary)
• Bordetella bronchiseptica (immunology)
• Female
• Pasteurella Infections (immunology, prevention & control, veterinary)
• Pasteurella multocida (immunology)
• Pregnancy
• Rhinitis, Atrophic (immunology, prevention & control, veterinary)
• Swine
• Swine Diseases (immunology, prevention & control)
• Vaccines, Combined (administration & dosage)