Abstract | OBJECTIVES: DESIGN: Prospective clinical study. SETTING: Pediatric intensive care unit. PATIENTS: MEASUREMENTS: RESULTS:
Palmitic acid and glycerol turnover were 5.6 +/- 2.2 micromol/kg/min and 12.2 +/- 7.3 micromol/kg/min, respectively, whereas alpha-ketoisocaproic turnover was 4.9 +/- 2.8 micromol/kg/min. Alpha-ketoisocaproic turnover positively correlated (R = 0.7, p = .03) with duration of pediatric intensive care unit admission and with prealbumin and RBP serum levels (R = 0.9, p = .001). Insulin-like growth factor binding protein (IGFBP)-2 was significantly higher and IGFBP-3 was significantly lower in critically ill children (p = .03 and p = .04 vs. recovery phase, respectively). No other hormonal differences were found. Serum albumin was significantly lower in sick children. We found a significant correlation between prealbumin and RBP and IGFBP-3 (R = 0.6, p = 0.03 and R = 0.6, p = .04, respectively). Alpha-ketoisocaproic turnover positively correlated with IGFBP-1 (R = 0.79, p = .01) and did not correlate with insulin-like growth factor I (R = -0.5, p = .15 [not significant]) No other correlations were found. Lipid turnover measurements did not correlate with any endogenous hormone levels or with duration of critical illness. CONCLUSION:
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Authors | Paola E Cogo, Virgilio P Carnielli, Federica Rosso, Arianna Cesarone, Giuseppe Giordano, Diego Faggian, Mario Plebani, Antonina Barreca, Franco Zacchello |
Journal | Critical care medicine
(Crit Care Med)
Vol. 30
Issue 1
Pg. 65-70
(Jan 2002)
ISSN: 0090-3493 [Print] United States |
PMID | 11902289
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- C-Peptide
- Carbon Radioisotopes
- Insulin
- Insulin-Like Growth Factor Binding Proteins
- Keto Acids
- Proteins
- Retinol-Binding Proteins
- Retinol-Binding Proteins, Plasma
- Triiodothyronine
- Palmitic Acid
- alpha-ketoisocaproic acid
- Thyrotropin
- Growth Hormone
- Leucine
- Glycerol
- Thyroxine
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Topics |
- C-Peptide
(metabolism)
- Carbon Radioisotopes
- Child, Preschool
- Critical Illness
- Glycerol
(metabolism)
- Growth Hormone
(metabolism)
- Humans
- Infant
- Infant, Newborn
- Insulin
(metabolism)
- Insulin Secretion
- Insulin-Like Growth Factor Binding Proteins
(metabolism)
- Keto Acids
(metabolism)
- Leucine
(metabolism)
- Lipolysis
(physiology)
- Palmitic Acid
(metabolism)
- Proteins
(metabolism)
- Retinol-Binding Proteins
(metabolism)
- Retinol-Binding Proteins, Plasma
- Thyrotropin
(metabolism)
- Thyroxine
(metabolism)
- Triiodothyronine
(metabolism)
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