HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Long-term effects of carotid sinus denervation on arterial blood pressure in humans.

AbstractBACKGROUND:
After experimental carotid sinus denervation in animals, blood pressure (BP) level and variability increase markedly but normalize to preoperative levels within 10 to 14 days. We investigated the course of arterial BP level and variability after bilateral denervation of the carotid sinus baroreceptors in humans.
METHODS AND RESULTS:
We studied 4 women (age 41 to 63 years) who were referred for evaluation of arterial baroreflex function because of clinical suspicion of carotid sinus denervation attributable to bilateral carotid body tumor resection. The course of BP level and variability was assessed from repeated office and 24-hour ambulatory measurements (Spacelabs/Portapres) during 1 to 10 years of (retrospective) follow-up. Rapid cardiovascular reflex adjustments to active standing and Valsalva's maneuver were assessed. Office BP level increased from 132/86 mm Hg (range, 118 to 148/80 to 92 mm Hg) before bilateral surgery to 160/105 mm Hg (range, 143 to 194/90 to 116 mm Hg) 1 to 10 years after surgery. During continuous 24-hour noninvasive BP recording (Portapres), a marked BP variability was apparent in all 4 patients. Initial symptomatic hypotension on change to the upright posture and abnormal responses to Valsalva's maneuver were observed.
CONCLUSIONS:
Acute carotid sinus denervation, as a result of bilateral carotid body tumor resection, has a long-term effect on the level, variability, and rapid reflex control of arterial BP. Therefore, in contrast to earlier experimental observations, the compensatory ability of the baroreceptor areas outside the carotid sinus seems to be of limited importance in the regulation of BP in humans.
AuthorsArthur A J Smit, Henri J L M Timmers, Wouter Wieling, Mariette Wagenaar, Henri A M Marres, Jacques W M Lenders, Gert A van Montfrans, John M Karemaker
JournalCirculation (Circulation) Vol. 105 Issue 11 Pg. 1329-35 (Mar 19 2002) ISSN: 1524-4539 [Electronic] United States
PMID11901044 (Publication Type: Journal Article)
Topics
  • Adult
  • Baroreflex
  • Blood Pressure
  • Blood Pressure Monitoring, Ambulatory
  • Cardiovascular Surgical Procedures (adverse effects)
  • Carotid Body Tumor (surgery)
  • Denervation (adverse effects)
  • Female
  • Heart Rate
  • Humans
  • Hypertension (diagnosis, etiology, physiopathology)
  • Middle Aged
  • Posture
  • Retrospective Studies
  • Time
  • Valsalva Maneuver

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: