Liquid ventilation with perflubron in the treatment of rats with pneumococcal pneumonia.

Abstract

OBJECTIVE:

To determine the efficacy of liquid ventilation using a medical-grade perfluorocarbon (perflubron) combined with parenteral or intratracheal antibiotics in a rat model of pneumonia.

DESIGN:

Prospective, laboratory investigation.

SETTING:

Experimental laboratory in a university medical center.

SUBJECTS:

Wistar rats (n = 112).

INTERVENTIONS:

One day after intratracheal inoculation with Streptococcus pneumoniae, rats received one of five experimental treatments or no treatment (control): modified liquid ventilation (MLV), intramuscular ampicillin, MLV plus intramuscular ampicillin, MLV with intratracheal ampicillin, or MLV plus ampicillin PulmoSpheres.

MEASUREMENTS AND MAIN RESULTS:

Animals receiving MLV plus intramuscular ampicillin, MLV with intratracheal ampicillin, or MLV plus ampicillin PulmoSpheres had significantly improved 10-day survival rates (85%, 72%, and 72%, respectively) compared with all other groups (0% to 25%).

CONCLUSIONS:

MLV in combination with either intramuscular, intratracheal, or PulmoSpheres ampicillin improved survival as compared with MLV alone or the same dose of antibiotics delivered intramuscularly.

• Authors: Eric W Dickson, Stephen O Heard, Thomas E Tarara, Jeffry G Weers, Angela B Brueggemann, Gary V Doern
• Journal: Critical care medicine (Crit Care Med) Vol. 30 Issue 2 Pg. 393-5 (Feb 2002) ISSN: 0090-3493 [Print] United States
• PMID: 11889317 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Fluorocarbons
• Hydrocarbons, Brominated
• perflubron

Topics

• Animals
• Anti-Bacterial Agents (administration & dosage)
• Combined Modality Therapy
• Fluorocarbons (administration & dosage)
• Hydrocarbons, Brominated
• Infusions, Parenteral
• Liquid Ventilation
• Male
• Pneumonia, Pneumococcal (mortality, therapy)
• Random Allocation
• Rats
• Rats, Wistar
• Statistics, Nonparametric
• Survival Analysis